Psychotic Disorders: Comprehensive Conceptualization and Treatments

Psychotic Disorders: Comprehensive Conceptualization and Treatments

Edited by Carol A. Tamminga, Jim van Os, Ulrich Reininghaus, and Elena Ivleva

Abstract

Psychotic Disorders: Comprehensive Conceptualization and Treatments emphasizes a dimensional approach to psychosis that cuts across a broad array of psychiatric diagnoses from schizophrenia to affective psychosis and organic disorders like epilepsy and dementias. Written by an international roster of over seventy leading experts in the field, this volume comprehensively reviews, critiques, and integrates available knowledge on the etiology, mechanisms, and treatments of psychotic disorders, and outlines ways forward in both research and clinical practice towards more objective, mechanistically-based definitions of psychotic disorders. Chapters address topics such as psychosis phenomenology, biomarkers and treatments, the overlaps and interfaces between psychiatric disorders within the psychosis dimension, and novel disease definitions. The book also incorporates findings on potential mechanisms, bridges between various system levels and their interactions, as well as the potential role in causation and/or mediation in psychotic disorders. Covering a broad array of treatment approaches and concluding with a section of forward perspectives, Psychotic Disorders aspires to stimulate new knowledge, generate novel frameworks, and carry new directions forward on psychotic disorders.

Bibliographic Information

Publisher:: Oxford University Press

Print Publication Date:: Nov 2020

Print ISBN-13:: 9780190653279

Published online:: Oct 2020

DOI:: 10.1093/med/9780190653279.001.0001

Authors

Carol A. Tamminga, editor University of Texas Southwestern Medical Center

Jim van Os, editor Maastricht University Medical Centre

Ulrich Reininghaus, editor Maastricht University

Elena Ivleva, editor University of Texas Southwestern Medical Center

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Front Matter
- Preface
- Contributors
Section 1 Phenomenological characteristics and dimensional conceptualization of psychosis
- 1 Conceptualization of psychosis in psychiatric nosology: Past, present, and the futureMatcheri S. Keshavan, John Torous, and Rajiv Tandon
- 2 Historical epistemology of the “unitary psychosis”German E. Berrios and Ivana S. Marková
- 3 Dimensional conceptualization of psychosisKürşat Altınbaş, Sinan Guloksuz, and Jim van Os
- Transdiagnostic dimensions of psychosis
  - 4 Applying Research Domain Criteria (RDoC) dimensions to psychosisSarah E. Morris, Jennifer Pacheco, and Charles A. Sanislow
  - 5 Schizophrenia, schizoaffective disorder, bipolar disorderBarrett Kern and Sarah K. Keedy
  - 6 Psychotic symptoms in bipolar disorderMarsal Sanches, Xiang-Yang Zhang, and Jair C. Soares
  - 7 Major depressive disorder with psychotic features: Confronting and resolving the dimensional challengeJohn L. Waddington, Tara Kingston, Nnamdi Nkire, and Vincent Russell
  - 8 Psychosis in personality disordersK. Nidhi Kapil-Pair, Yulia Landa, Marie C. Hansen, Daniel H. Vaccaro, and Marianne Goodman
  - 9 Symptom network models of psychosisAdela-Maria Isvoranu, Lindy-Lou Boyette, Sinan Guloksuz, and Denny Borsboom
- Psychosis in general medical conditions and organic brain disorders
  - 10 Organic psychosis: Phenotypic deviants or clues to schizophrenia?Peter Buckley and Brian Miller
  - 11 Epilepsy and psychosisMichael R. Trimble, Kousuke Kanemoto, and Dale C. Hesdorffer
  - 12 Understanding sex differences in psychosis through the exploration of hormonal contributionsLeah H. Rubin
Section 2 Psychosis course and lifetime manifestations
- Early psychosis
  - 13 Clinical phenomenology of the prodrome for psychosisAlbert R. Powers III, Thomas H. McGlashan, and Scott W. Woods
  - 14 Predictors of conversion to psychosisRachael G. Grazioplene and Tyrone D. Cannon
  - 15 First-episode psychosis: Phenomenology, onset, course, and early intervention (OPUS)Merete Nordentoft and Nikolai Albert
  - 16 Evidence-based treatment and implementation for early psychosisSacha Zilkha, Iruma Bello, Hong Ngo, Samantha Jankowski, and Lisa Dixon
- Psychosis over life span and late-life psychosis
  - 17 Life span development of schizophrenia: Symptoms, clinical course, and outcomesMatti Isohanni, Jouko Miettunen, and Matti Penttilä
  - 18 Phenomenological characteristics of psychosis of aging: Psychosis and dementia interphaseGraham M. L. Eglit, Barton W. Palmer, and Dilip V. Jeste
Section 3 Neurobiology of psychosis
- Heritability and genetics
  - 19 Genetic neuropathology revisited: Gene expression in psychosisSamuel J. Allen, Rahul Bharadwaj, Thomas M. Hyde, and Joel E. Kleinman
  - 20 Epigenomic regulation in psychosisBibi S. Kassim, Behnam Javidfar, and Schahram Akbarian
  - 21 DNA modifications in schizophreniaEhsan Pishva and Bart P. F. Rutten
  - 22 Endophenotypes: A window on the genetics of schizophreniaDavid Braff
- Cognitive biomarkers of psychosis
  - 23 Cognitive biomarkers of psychosisS. Kristian Hill, Richard S. E. Keefe, and John A. Sweeney
  - 24 Social cognition in psychosisAmy E. Pinkham and David L. Roberts
  - 25 Self-awareness in schizophrenia: Affected domains and their impactJuliet M. Silberstein, Amy E. Pinkham, and Philip D. Harvey
- Neurophysiologic biomarkers of psychosis
  - 26 Neurophysiologic biomarkers of psychosis: Event-related potential biomarkersJudith M. Ford, Holly K. Hamilton, Katiah Llerena, Brian J. Roach, and Daniel H. Mathalon
  - 27 Oculomotor biomarkers of illness, risk, and pharmacogenetic treatment effects across the psychosis spectrumJames L. Reilly, Jennifer McDowell, Jeffrey Bishop, Andreas Sprenger, and Rebekka Lencer
- Brain imaging biomarkers
  - 28 Structural connectivity in psychosisAmanda E. Lyall, Johanna Seitz, and Marek Kubicki
  - 29 Functional connectivity biomarkers of psychosisGodfrey Pearlson and Michael Stevens
  - 30 MR spectroscopyAdrienne C. Lahti and Nina V. Kraguljac
- Pathophysiology of psychosis: Neurotransmitters
  - 31 Dopaminergic mechanisms underlying psychosisMichael A. P. Bloomfield and Oliver D. Howes
  - 32 Glutamate in the pathophysiology of schizophreniaDaniel C. Javitt
  - 33 GABAergic mechanisms in psychosisTakanori Hashimoto and David A. Lewis
  - 34 Alteration in nicotinic receptors in psychotic disorders: Molecular neurobiology and clinical relevanceRobert Freedman
  - 35 Muscarinic acetylcholine receptors in the etiology and treatment of schizophreniaM. S. Moehle, S. E. Yohn, and P. J. Conn
  - 36 Kynurenic acid in brain function and dysfunction: Focus on the pathophysiology and treatment of schizophreniaRobert Schwarcz and Sophie Erhardt
- Pathophysiology: Voltage-gated ion channels in psychosis
  - 37 Genetic association of voltage-gated ion channels with psychotic disordersCharles H. Large
  - 38 Voltage-gated ion channels in neural circuits implicated in psychotic disordersCharles H. Large
- Pathophysiology: Immune mechanisms
  - 39 Inflammatory mechanisms in psychosisAnna P. McLaughlin, Carmine M. Pariante, and Valeria Mondelli
  - 40 Autoimmune processes in mental disordersMarina Mané-Damas, Carolin Hoffmann, Shenghua Zong, Peter C. Molenaar, Mario Losen, and Pilar Martinez-Martínez
- Brain circuit alterations in psychosis
  - 41 The circuitry of midbrain dopamine system dysregulation in schizophreniaFelipe V. Gomes, Eric C. Zimmerman, and Anthony A. Grace
  - 42 Feeling and remembering: Effects of psychosis on the structure and function of the amygdala and hippocampusM. D. Bauman, J. D. Ragland, and C. M. Schumann
  - 43 The cerebellum in psychosisKelsey Heslin, Joseph J. Shaffer, Albert Powers, Nancy Andreasen, and Krystal Parker
Section 4 Socioenvironmental mechanistic factors in psychosis
- Early life adversity
  - 44 Perinatal factors in psychosisMary Clarke and Mary Cannon
  - 45 The role of early life experience in psychosisRichard P. Bentall
  - 46 Socioenvironmental adversity across the life spanPeter Bosanac and David J. Castle
  - 47 Migration, ethnicity, and psychosesCraig Morgan
- Psychological mechanisms and psychosis
  - 48 Cognitive and emotional processes in psychosisSteffen Moritz, Thies Lüdtke, Łukasz Gawęda, Jakob Scheunemann, and Ryan P. Balzan
  - 49 Aberrant salience attribution and psychosisToby T. Winton-Brown and Shitij Kapur
- Neural correlates of socioenvironmental risk and psychosis
  - 50 Neural correlates of childhood traumaAlaptagin Khan, Kyoko Ohashi, Maria Maier, and Martin H. Teicher
  - 51 Neural correlates of urban risk environmentsImke L. J. Lemmers-Jansen, Anne-Kathrin J. Fett, and Lydia Krabbendam
  - 52 Neural correlates of ethnic minority position and risk for psychosisJean-Paul Selten, Jan Booij, Bauke Buwalda, and Andreas Meyer-Lindenberg
  - 53 Resilience in psychosis spectrum disorderLotta-Katrin Pries, Sinan Guloksuz, and Bart P. F. Rutten
Section 5 Treatment of psychotic disorders
- Pharmacological treatments
  - 54 Pharmacological approaches to treatmentStefan Leucht, Andrea Cipriani, and Toshi A. Furukawa
  - 55 Animal models of psychosis: Approaches and validityDaniel Scott
- Psychological treatments in psychosis
  - 56 Psychoanalytic treatment of psychosisElyn R. Saks
  - 57 Cognitive-behavioral therapyTania Lincoln and Alison Brabban
  - 58 Psychoeducation as an approach to treatment of severe mental illnessEmma Sophia Kay, David E. Pollio, and Carol S. North
  - 59 Family interventions in psychosisJuliana Onwumere and Elizabeth Kuipers
  - 60 Peer support for people with psychiatric illness: A comprehensive reviewChyrell D. Bellamy, Anne S. Klee, Xavier Cornejo, Kimberly Guy, Mark Costa, and Larry Davidson
  - 61 Mindfulness and acceptance based therapies for psychosisLouise Johns, Mark Hayward, Clara Strauss, and Eric Morris
  - 62 Hearing voices groupsAlison Branitsky, Eleanor Longden, and Dirk Corstens
  - 63 AVATAR therapy: A new digital therapy for auditory verbal hallucinationsTom K. J. Craig and Mar Rus-Calafell
  - 64 Health in a connected worldPhilippe Delespaul and Catherine van Zelst
- Cognitive remediation and other approaches
  - 65 Recovery-oriented servicesMike Slade, Eleanor Longden, Julie Repper, and Samson Tse
  - 66 Neuroscience-informed cognitive training for psychotic spectrum illnessesSophia Vinogradov, Rana Elmaghraby, and Laura Pientka
  - 67 Cognitive remediation: Theory, meta-analytic evidence, and practiceTil Wykes and Adam Crowther
  - 68 Noninvasive brain stimulation techniques in psychosisMarine Mondino, Frédéric Haesebaert, and Jérôme Brunelin
- Early interventions
  - 69 Treatment approaches in the psychosis prodromeAndrea M. Auther and Barbara A. Cornblatt
  - 70 From early intervention in psychosis to transformation of youth mental health reformAshok Malla and Patrick McGorry
Section 6 Future directions and opportunities
- 71 Future directions: Making a start toward the primary prevention of psychosisRobin M. Murray, Olesya Ajnakina, and Marta Di Forti
- 72 A glimpse forward regarding psychopathology of psychotic disordersWilliam T. Carpenter
- 73 Time for change in psychosis researchBrett A. Clementz
End Matter
- Index

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Edited by Carol A. Tamminga, Jim van Os, Ulrich Reininghaus, and Elena Ivleva

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Edited by Carol A. Tamminga, Jim van Os, Ulrich Reininghaus, and Elena Ivleva

Abstract

Bibliographic Information

Authors

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Contents