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Neural Stem Cell Therapy for Temporal Lobe Epilepsy 

Neural Stem Cell Therapy for Temporal Lobe Epilepsy
Chapter:
Neural Stem Cell Therapy for Temporal Lobe Epilepsy
Author(s):

Ashok K. Shetty

DOI:
10.1093/med/9780199746545.003.0085
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date: 14 November 2018

The major objective of this chapter is to evaluate the contemporary knowledge and to put forward perspectives concerning the NSC grafting therapy for TLE. Since the efficiency of grafting of neural progenitors obtained from the fetal brain or ES cells are covered in other chapters in this book, this chapter is deliberately confined to studies on the efficacy of NSC grafts in TLE prototypes. The first section will focus on the prospects for preventing or minimizing SRS using NSC grafting procedures that are performed shortly after the initial precipitating injury (IPI), such as SE or a direct excitotoxic lesion. The second section will consider the promise of NSC grafting therapy for restraining seizures and easing cognitive dysfunction when applied shortly after or at prolonged periods after the onset of SE- or kindling- induced TLE. Several critical issues that need to be resolved before initiating the clinical application of NSC grafting therapy for TLE are also discussed.

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