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Hyperpolarization-Activated Cyclic Nucleotide-Gated (HCN) Ion Channelopathy in Epilepsy 

Hyperpolarization-Activated Cyclic Nucleotide-Gated (HCN) Ion Channelopathy in Epilepsy

Chapter:
Hyperpolarization-Activated Cyclic Nucleotide-Gated (HCN) Ion Channelopathy in Epilepsy
Author(s):

Nicholas P. Poolos

DOI:
10.1093/med/9780199746545.003.0007
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date: 09 July 2017

This chapter describes how the unique biophysical properties of HCN channels lead to an influential role in seizure generation; whether recent evidence truly supports the existence of HCN channelopathy in human epilepsy; and how the mechanisms underlying acquired HCN dysfunction could be targeted by antiepileptic therapies.

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