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Potassium Channels (Including KCNQ) and Epilepsy 

Potassium Channels (Including KCNQ) and Epilepsy

Chapter:
Potassium Channels (Including KCNQ) and Epilepsy
Author(s):

Edward C. Cooper

DOI:
10.1093/med/9780199746545.003.0005
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date: 09 July 2017

This chapter aims to provide a perspective on the achievements and future potential of studies of potassium channels in epilepsy research. The thesis is that the understanding obtained from recent studies justifies continued investment in K+ channels by academic and industry-based researchers. We first reintroduce the K+ channels, highlighting progress that appears particularly relevant to epilepsy. Then, as an example, we provide a detailed account of one K+ channel subfamily, the KCNQ/Kv7 family. Members of this family are mutated in benign familial neonatal seizures, an autosomal dominant syndrome. Moreover, these channels have been found to be practical targets for antiepileptic drug development, perhaps providing a model for studies of other K+ channel subgroups. We conclude with a discussion of directions for future work.

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