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Management of Treatment-Resistant Schizophrenia 

Management of Treatment-Resistant Schizophrenia
Management of Treatment-Resistant Schizophrenia

Jacob S. Ballon

and Jeffrey A. Lieberman

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date: 12 November 2018

Schizophrenia continues to be among the most disabling disorders in psychiatry, and it often requires several attempts at treatment before finding the right regimen. Prognostic factors such as age of onset, types of symptoms, and treatment patterns can be influential in the overall outcome. The goal of treatment in schizophrenia should be to achieve recovery from the illness, beyond just amelioration of hallucinations or delusions. This often requires pharmacotherapy, nonmedication somatic therapies, psychotherapy, and other treatment modalities. Often in the course of schizophrenia, other psychiatric comorbidities are present and can influence the plan for care. For those who do not recover with the first few attempts at treatment, this chapter provides a review of evidence-based techniques and other ideas for clinicians to use with patients to achieve the best clinical response.

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