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The applicability of trials of complex mental health interventions 

The applicability of trials of complex mental health interventions
Chapter:
The applicability of trials of complex mental health interventions
Author(s):

Lara Fairall

, Merrick Zwarenstein

, and Graham Thornicroft

DOI:
10.1093/med/9780199680467.003.0002
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date: 22 November 2017

The evidence on what interventions are currently known to be effective in mental health is summarized in the 2009 PLoS Medicine series on packages of care for mental, neurological, and substance-use disorders in LAMIC and the WHO mhGAP guidelines published in 2010. But far less is known about how best to deliver and scale-up these interventions in real-life settings. How to translate this evidence into practice, in ways that are culturally appropriate and sensitive has been identified as the key research priority in global mental health. This chapter discusses the potential contribution of trials to the genesis of interventions that are both effective and highly applicable to real-world settings by considering two frameworks : the development–evaluation–implementation process proposed by the Medical Research Council (MRC) in Britain in their 2000 and 2008 guidance on developing and evaluating complex interventions and the PRagmatic Explanatory Continuum Indicator Summary (PRECIS) tool.

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