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The immunocompromised host: (b) patients with haematological disorders 

The immunocompromised host: (b) patients with haematological disorders
The immunocompromised host: (b) patients with haematological disorders

Jeremy Brown

and James Brown

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date: 20 November 2017

Key points

Patients with haematological malignancy or who have had haematopoietic stem cell transplantation (HSCT) are often severely immunosuppressed, both due to the disease and as a result of the treatment - Infectious complications affecting the respiratory tract are common and frequently severe in these patients - There is a large range of pathogens that cause respiratory infections in haematology patients, and opportunistic infection with cytomegalovirus, species, and are common - The likely microbial pathogen(s) can be narrowed down by assessment of the patient's underlying immune defect(s), the clinical presentation, the radiological features on the CT scan, and carefully targeted investigations - Early use of empirical broad-spectrum antibiotics is essential in these patients if they present with symptoms or signs of a respiratory infection - Expert advice is necessary unless there is a rapid response to empirical antibiotics.

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