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Future treatments 

Future treatments
Future treatments

Uta Griesenbach

, Jane Davies

, and Eric Alton

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date: 17 March 2018

Increased understanding of CF pathophysiology is leading to new therapies

Several gene therapy trials have established proof-of-principle for gene transfer in the airways, but a gene therapy-based treatment has not yet been developed

Small molecule drugs directed at class-specific CFTR mutations are showing promise in early phase trials

Drugs aimed at restoring hydration of the airway surface have been shown to improve mucociliary clearance

Increasing numbers of antibiotics are being formulated for both nebulization and inhalation.

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