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Oxford University Press makes no representation, express or implied, that the drug dosages in this book are correct. Readers must therefore always check the product information and clinical procedures with the most up to date published product information and data sheets provided by the manufacturers and the most recent codes of conduct and safety regulations. The authors and the publishers do not accept responsibility or legal liability for any errors in the text or for the misuse or misapplication of material in this work. Except where otherwise stated, drug dosages and recommendations are for the non-pregnant adult who is not breastfeeding.

Iatrogenic heart failure

Chapter:
Iatrogenic heart failure
Author(s):

Martin Denvir

DOI:
10.1093/med/9780199577729.003.0009

Heart failure (HF) can result from adverse or unwanted effects oftreatment for unrelated conditions. Iatrogenic literally means anillness or condition generated by the physician (from the Greekiatros, a physician, and genic meaning ‘induced by’). In the acutesetting, the physician can induce HF — in a patient without anyclinically overt cardiac disease — by the inadvertent use of high volumes of fluid, or drugs known to depress cardiac function; or duringcardiac surgery when the left ventricle experiences injury (eitherdirectly or indirectly) while on cardiopulmonary bypass. ChronicHF, on the other hand, is more common in patients treated forlymphoma, breast cancer, or more rarely lung cancer. In this clinicalsetting, the patient may present many months or years after theinitial injury to the heart resulting from chemotherapeutic agentsand/or radiotherapy. This chapter outlines the main causes of HFinduced by the physician in the acute setting, and focuses on theepidemiology, presentation, and treatment of chronic HF syndromesresulting from treatment of childhood and adult cancers.

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