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Pathophysiology in fibromyalgia syndrome 

Pathophysiology in fibromyalgia syndrome
Pathophysiology in fibromyalgia syndrome

Ernest Choy

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date: 21 September 2018

Pain processing is complex and involves nociception, transmission, modulation, and perception.

Objective examination using function neuroimaging has demonstrated that pain in patients with fibromyalgia syndrome (FMS) is ‘real’.

Physiological pain is important in protecting us from harm, while maladaptive (pathologic) pain injury is caused by functional abnormality of the nervous system. FMS is characterized by maladaptive pain.

Sleep study in patients with FMS has confirmed reduced deep quality and increased wakefulness. In healthy volunteers, selective deprivation of non-REM sleep can induce symptoms and hyperalgesic tender sites of FMS.

Patients with FMS often report experiencing previous stressful or traumatic events. A reduced HPA axis response to stress can contribute to development or worsening of FMS.

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