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Oxford Textbook of Endocrinology and Diabetes$
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Oxford Textbook of Endocrinology and Diabetes (2 ed.)

Edited by John A.H. Wass, Paul M. Stewart, Stephanie A. Amiel, Melanie C. Davies

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Publisher:
Oxford University Press
Print Publication Date:
Jul 2011
Print ISBN-13:
9780199235292
Published to Oxford Medicine:
Jul 2011
DOI:
10.1093/med/9780199235292.001.1

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Oxford University Press makes no representation, express or implied, that the drug dosages in this book are correct. Readers must therefore always check the product information and clinical procedures with the most up to date published product information and data sheets provided by the manufacturers and the most recent codes of conduct and safety regulations. The authors and the publishers do not accept responsibility or legal liability for any errors in the text or for the misuse or misapplication of material in this work. Except where otherwise stated, drug dosages and recommendations are for the non-pregnant adult who is not breastfeeding.

Contents

Microvascular complications

Disturbed microvascular function precedes clinically apparent microvascular complications. Complications are not confined to the eye and the kidney; they occur in many tissues, e.g. the heart and brain. Microvascular complications are the result of the combined effects of hyperglycaemia and haemodynamic factors on cells, modulated by genetic predisposition (Fig. 13.5.1.1). The intracellular pathway involved varies with the stage (i.e. whether in the initiation or progressive phase) and organ (kidney, eye), and may be modified by treatment. This chapter describes the generic factors involved in the pathogenesis of microvascular complications. Further details are available in recent reviews (1–10).

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