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Contents
- Front Matter
- Part 1 Principles of international endocrine practice
- 1.1 A brief history of endocrinology
- 1.2 Prevention in endocrinology
- 1.3 Endocrinology and evolution: lessons from comparative endocrinology
- 1.4 Hormones and receptors: fundamental considerations
- 1.5 Molecular aspects of hormonal regulation
- 1.6 Endocrine autoimmunity
- 1.7 Measurement of hormones
- 1.8 Endocrine disruptors
- 1.9 Sports endocrinology: the use and abuse of performance-enhancing hormones and drugs
- Part 2 Pituitary and hypothalamic diseases
- 2.1 General concepts of hypothalamus-pituitary anatomy
- 2.2 The neurohypophysis
- 2.3 Aetiology, pathogenesis, and management of disease of the pituitary
- 2.3.1 Development of the pituitary and genetic forms of hypopituitarism
- 2.3.2 Molecular pathogenesis of pituitary tumours
- 2.3.3 Histopathology of pituitary tumours
- 2.3.4 Pituitary assessment strategy
- 2.3.5 Imaging of the pituitary
- 2.3.6 Hypopituitarism: replacement of adrenal, thyroid, and gonadal axes
- 2.3.7 Adult growth hormone deficiency
- 2.3.8 Surgery of pituitary tumours
- 2.3.9 Pituitary radiotherapy
- 2.3.10 Prolactinomas and hyperprolactinaemia (including macroprolactinaemia)
- 2.3.11 Acromegaly
- 2.3.12 Clinically nonfunctioning pituitary tumours and gonadotropinomas
- 2.3.13 Thyrotropinomas
- 2.3.14 Pituitary carcinoma
- 2.3.15 Pituitary incidentalomas
- 2.4 Aetiology, pathogenesis, and management of diseases of the hypothalamus
- 2.5 Pineal physiology and pathophysiology, including pineal tumours
- 2.6 Neuropsychiatric endocrinological disorders
- Part 3 The thyroid
- 3.1 Evaluation of the thyroid patient
- 3.1.1 The history and iconography relating to the thyroid gland
- 3.1.2 Biosynthesis, transport, metabolism, and actions of thyroid hormones
- 3.1.3 Clinical assessment of the thyroid patient
- 3.1.4 Thyroid function tests and the effects of drugs
- 3.1.5 Nonthyroidal illness
- 3.1.6 Thyroid imaging: nuclear medicine techniques
- 3.1.6.1 Thyroid imaging: nonisotopic techniques
- 3.1.7 Epidemiology of thyroid disease and swelling
- 3.2 Aetiology of thyroid disorders
- 3.3 Thyrotoxicosis and related disorders
- 3.3.1 Clinical assessment and systemic manifestations of thyrotoxicosis
- 3.3.2 Thyrotoxic periodic paralysis
- 3.3.3 Thyrotoxic storm
- 3.3.4 Subclinical hyperthyroidism
- 3.3.5 Causes and laboratory investigations of thyrotoxicosis
- 3.3.6 Antithyroid drug treatment for thyrotoxicosis
- 3.3.7 Radio-iodine treatment of hyperthyroidism
- 3.3.8 Surgery for thyrotoxicosis
- 3.3.9 Management of Graves’ hyperthyroidism
- 3.3.10 Graves’ ophthalmopathy and dermopathy
- 3.3.11 Management of toxic multinodular goitre and toxic adenoma
- 3.3.12 Management of thyrotoxicosis without hyperthyroidism
- 3.4 Hypothyroidism and pregnancy- and growth-related thyroid disorders
- 3.4.1 Clinical assessment and systemic manifestations of hypothyroidism
- 3.4.2 Causes and laboratory investigation of hypothyroidism
- 3.4.3 Myxoedema coma
- 3.4.4 Subclinical hypothyroidism
- 3.4.5 Thyroid disease during pregnancy
- 3.4.6 Thyroid disease after pregnancy: postpartum thyroiditis
- 3.4.7 Thyroid disease in newborns, infants, and children
- 3.4.8 Thyroid hormone resistance syndrome
- 3.4.9 Treatment of hypothyroidism
- 3.5 Thyroid lumps
- 3.5.1 Pathogenesis of nontoxic goitre
- 3.5.2 Management of nontoxic multinodular goitre
- 3.5.3 Management of the single thyroid nodule
- 3.5.4 Pathogenesis of thyroid cancer
- 3.5.5 Pathology of thyroid cancer
- 3.5.6 Papillary, follicular, and anaplastic thyroid carcinoma and lymphoma
- 3.5.7 Medullary thyroid carcinoma
- 3.1 Evaluation of the thyroid patient
- Part 4 Parathyroid, calcium, and bone metabolism
- 4.1 Parathyroid anatomy, hormone synthesis, secretion, action, and receptors
- 4.2 Hypercalcaemia
- 4.3 Primary hyperparathyroidism
- 4.4 Familial hypocalciuric hypercalcaemia
- 4.5 Hypocalcaemic disorders, hypoparathyroidism, and pseudohypoparathyroidism
- 4.6 Hypercalcaemic and hypocalcaemic syndromes in children
- 4.7 Osteoporosis
- 4.8 Thyroid disorders and bone disease
- 4.9 Paget’s disease of bone
- 4.10 Rickets and osteomalacia (acquired and heritable forms) and skeletal dysplasias
- 4.11 Glucocorticoid-induced osteoporosis
- Part 5 The adrenal gland and endocrine hypertension
- 5.1 Adrenal imaging
- 5.2 Adrenal surgery
- 5.3 Adrenal incidentaloma
- 5.4 Adrenocortical cancer
- 5.5 Phaeochromocytomas, paragangliomas, and neuroblastoma
- 5.6 Primary aldosteronism and other steroid-related causes of endocrine hypertension
- 5.7 Cushing’s syndrome
- 5.8 Glucocorticoid resistance—a defect of the glucocorticoid receptor
- 5.9 Adrenal insufficiency
- 5.10 Familial glucocorticoid deficiency
- 5.11 Congenital adrenal hyperplasia
- Part 6 Neuroendocrine tumours and genetic disorders
- 6.1 Neuroendocrine tumours of the gastrointestinal tract: an appraisal of the past and perspectives for the future
- 6.2 Neuroendocrine tumour markers
- 6.3 Neuroendocrine (carcinoid) tumours and the carcinoid syndrome
- 6.4 Gastrinoma
- 6.5 Insulinoma and hypoglycaemia
- 6.6 Glucagonoma
- 6.7 VIPomas
- 6.8 Somatostatinoma
- 6.9 Imaging neuroendocrine tumours of the gastrointestinal tract
- 6.10 Systemic mastocytosis
- 6.11 Multiple endocrine neoplasia type 1
- 6.12 Multiple endocrine neoplasia type 2
- 6.13 von Hippel–Lindau disease and succinate dehydrogenase subunit (SDHB, SDHC, and SDHD) genes
- 6.14 Neurofibromatosis
- 6.15 Carney’s complex
- 6.16 Molecular and clinical characteristics of the McCune–Albright syndrome
- 6.17 Cowden’s syndrome
- Part 7 Growth and development during childhood
- 7.1 Normal growth and sexual development
- 7.2 Growth and sexual disorders in childhood
- 7.2.1 Hypoglycaemia: assessment and management
- 7.2.2 Differential diagnosis of short stature and poor growth velocity
- 7.2.3 Genetic defects of the human somatotropic axis
- 7.2.4 Investigation of the slowly growing child
- 7.2.5 Growth hormone therapy for the growth-hormone deficient child
- 7.2.6 Growth-promoting agents for nongrowth hormone-deficient short children
- 7.2.7 Syndromic growth disorders
- 7.2.8 Tall stature
- 7.2.9 Delayed puberty and hypogonadism
- 7.2.10 Premature sexual maturation
- 7.3 Congenital adrenal hyperplasia in children
- 7.4 Late effects of cancer treatment
- 7.5 Transition in endocrinology
- Part 8 Female endocrinology and pregnancy
- 8.1 Female endocrinology and ovarian disorders
- 8.1.1 The generation and use of human embryonic stem cells
- 8.1.2 Menstrual cycle and ovulation
- 8.1.3 Hormonal contraception
- 8.1.4 Premenstrual syndrome
- 8.1.5 Primary ovarian failure
- 8.1.6 Disorders of gonadotropin secretion
- 8.1.7 Hyperprolactinaemic anovulation
- 8.1.8 Polycystic ovary syndrome: reproductive aspects
- 8.1.9 Polycystic ovary syndrome: metabolic aspects
- 8.1.10 Hirsutism
- 8.1.11 Infertility and assisted reproduction
- 8.1.12 Nutrition and reproduction
- 8.2 Pregnancy-related disorders
- 8.1 Female endocrinology and ovarian disorders
- Part 9 Male hypogonadism and infertility
- 9.1 Definitions and classification of disorders
- 9.2 Normal male endocrinology
- 9.3 Evaluation of the male patient with suspected hypogonadism and/or infertility
- 9.4 Male endocrinological disorders and male factor infertility
- 9.4.1 Congenital anorchia, acquired anorchia, testicular maldescent, and varicocele
- 9.4.2 Disturbed spermatogenesis
- 9.4.3 Klinefelter’s syndrome
- 9.4.4 XX male
- 9.4.5 XYY male
- 9.4.6 Structural chromosome abnormalities
- 9.4.7 Sequelae of extratesticular disease
- 9.4.8 Testicular tumours
- 9.4.9 Infections/inflammation of the genital tract
- 9.4.10 Obstructions
- 9.4.11 Immunological infertility
- 9.4.12 Idiopathic infertility
- 9.4.13 Treatment of hypogonadism and infertility
- 9.4.14 Insemination, in vitro fertilization, and intracytoplasmic sperm injection
- 9.4.15 Cryopreservation of sperm
- 9.4.16 Sexuality and erectile dysfunction
- 9.4.17 Gynaecomastia
- 9.4.18 Transsexualism
- 9.5 Exogenous factors and male reproductive health
- Part 10 Endocrinology of ageing and systemic disease
- Part 11 Endocrinology of cancer
- Part 12 Obesity, lipids, and metabolic disorders
- Part 13 Diabetes mellitus
- 13.1 Classification and diagnosis of diabetes mellitus
- 13.2 Aetiology and pathogenesis of type 1 diabetes mellitus
- 13.3 Aetiology and pathogenesis of type 2 diabetes mellitus
- 13.4 Management of diabetes mellitus
- 13.4.1 Clinical features, lifestyle management, and glycaemic targets in type 2 diabetes mellitus
- 13.4.2 Pharmacological therapy of hyperglycaemia in type 2 diabetes mellitus
- 13.4.3 Diabetes in diverse ethnic groups
- 13.4.4 Structured education for people with type 2 diabetes mellitus
- 13.4.5 Metabolic surgery in the treatment of type 2 diabetes mellitus
- 13.4.6 Management of type 1 diabetes mellitus
- 13.4.7 Type 1 and type 2 diabetes mellitus in children
- 13.4.8 Hypoglycaemia in the treatment of diabetes mellitus
- 13.4.9 Non-biological technologies in glucose sensing
- 13.4.10 Management of diabetes mellitus in special situations
- 13.4.10.1 Hyperglycaemic crises in adult patients with diabetes mellitus
- 13.4.10.2 Diabetic ketoacidosis in childhood and adolescence
- 13.4.10.3 Management of the inpatient with diabetes mellitus
- 13.4.10.4 Insulin therapy in the intensive care unit
- 13.4.10.5 Diabetes management in surgery
- 13.4.10.6 Diabetes management in pregnancy
- 13.5 Microvascular complications
- 13.6 Macrovascular diseases and diabetes mellitus
- 13.7 The diabetic foot
- 13.8 Mental health and diabetes mellitus
- 13.9 Organization of diabetes care
- 13.10 Transplantation in Diabetes
- 13.11 Gene therapy in diabetes mellitus
- End Matter