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Anaesthetic pharmacology in the elderly 

Anaesthetic pharmacology in the elderly
Anaesthetic pharmacology in the elderly

Chris Dodds

, Chandra M. Kumar

, and Frédérique Servin

Page of

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date: 18 September 2018

Initial distribution of drugs is often impaired.

Protein binding is less efficient.

Excretion of water-soluble drugs or metabolites is reduced.

Clearance of highly extracted drugs decreases with liver blood flow.

Inter-individual variability increases with age.

Titration to effect is mandatory.

Always favour the shortest acting and most titrable drugs.

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