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Blood and lymphatic vessel disorders 

Blood and lymphatic vessel disorders
Chapter:
Blood and lymphatic vessel disorders
Author(s):

Peter S. Mortimer

DOI:
10.1093/med/9780199204854.003.2312

November 28, 2013: This chapter has been re-evaluated and remains up-to-date. No changes have been necessary.

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date: 22 October 2017

Bleeding into the skin may occur for local reasons or as part of a systemic disorder. The distribution of lesions is important: widespread lesions suggest a systemic problem, whereas regional lesions suggest that local factors predominate.

Widespread flat purpura without erythema should prompt a search for underlying haematological abnormalities such as platelet disorders. Larger (>1 cm) areas of purpura or bruising usually result from coagulation dysfunction. Palpable purpuric lesions, or those with a blanching component, suggest an associated inflammation as can be seen with vasculitis....

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