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Haemopoietic stem cell transplantation 

Haemopoietic stem cell transplantation

Chapter:
Haemopoietic stem cell transplantation
Author(s):

E.C. Gordon-Smith

and Emma Morris

DOI:
10.1093/med/9780199204854.003.220802_update_001

Update:

Inclusion of additional data relating to the pathogenesis of GVHD.

Use of CXCR4 inhibitors for HSC mobilization.

Updated references.

Updated on 30 May 2013. The previous version of this content can be found here.
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date: 27 June 2017

Haemopoietic stem cells (HSC) give rise to the blood cell lineages and the cells of the immune system, and their transplantation may be an appropriate part of the management of conditions including (1) malignant haematological disorders e.g. leukaemia, lymphoma, myeloma (2) bone marrow failure syndromes—e.g. aplastic anaemia; (3) congenital disorders—(a) haematological—e.g. Fanconi’s anaemia; (b) immunological—severe combined immunodeficiency; (c) metabolic—e.g. lysosomal diseases....

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