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Haemolytic anaemia—congenital and acquired 

Haemolytic anaemia—congenital and acquired
Chapter:
Haemolytic anaemia—congenital and acquired
Author(s):

Amy Powers

, Leslie Silberstein

, and Frank J. Strobl

DOI:
10.1093/med/9780199204854.003.220509
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date: 11 December 2017

Premature destruction of red cells occurs through two primary mechanisms: (1) decreased erythrocyte deformability that leads to red-cell sequestration and extravascular haemolysis in the spleen and other components of the reticuloendothelial system—may be caused by membrane defects, metabolic abnormalities, exogenous oxidizing agents, or pathological antibodies; (2) red-cell membrane damage and intravascular haemolysis—may be caused by exposure to pathological antibodies, activated complement, mechanical forces, chemicals, and infectious agents....

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