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Normochromic, normocytic anaemia 

Normochromic, normocytic anaemia
Normochromic, normocytic anaemia

D.J. Weatherall


August 28, 2014: This chapter has been re-evaluated and remains up-to-date. No changes have been necessary.


Chapter reviewed June 2011—no substantial updates required.

Updated on 30 November 2011. The previous version of this content can be found here.
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date: 20 January 2019

A mild normochromic, normocytic anaemia is a common finding and usually a consequence of other diseases, including (1) anaemia of chronic disorders—associated with chronic infection, all forms of inflammatory diseases, and malignant disease; mechanism unknown but likely to involve multiple factors; typically leads to a reduction in the serum iron concentration with concurrent reduction in the level of transferrin, hence saturation of the iron binding capacity is usually normal or only slightly reduced; (2) other disorders—including renal failure, hypothyroidism, hypopituitarism, marrow failure (aplastic anaemia, infiltration, pure red-cell aplasia), acute blood loss, and polymyalgia rheumatica. Treatment is that of the underlying condition, with a therapeutic trial of corticosteroids justified—after exclusion of underlying blood dyscrasias and paraproteinaemias—in elderly patients with anaemia in association with a very high sedimentation rate....

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