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Iron metabolism and its disorders 

Iron metabolism and its disorders
Chapter:
Iron metabolism and its disorders
Author(s):

T.M. Cox

and John B. Porter

DOI:
10.1093/med/9780199204854.003.220504_update_001

Update:

Section on treatment updated.

Further reading updated.

Updated on 30 May 2013. The previous version of this content can be found here.
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date: 17 October 2017

Iron is a component of haem proteins and nonhaem enzyme systems required for oxygen transport, mitochondrial respiration, and other key metabolic reactions. The metal exists in two readily interconvertible redox states (divalent ferrous and trivalent ferric iron) that are highly reactive and toxic to tissues. High-affinity iron-binding proteins, which form stable ferric complexes, have evolved to facilitate iron transport and delivery to sites of storage and utilization, including haem biosynthesis....

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