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Paroxysmal nocturnal haemoglobinuria 

Paroxysmal nocturnal haemoglobinuria
Chapter:
Paroxysmal nocturnal haemoglobinuria
Author(s):

Lucio Luzzatto

DOI:
10.1093/med/9780199204854.003.220312
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date: 17 October 2017

Paroxysmal nocturnal haemoglobinuria (PNH) is a unique disorder in which a substantial proportion of the patient’s red cells have an abnormal susceptibility to activated complement. This results from the presence of a clone that originates from a haematopoietic stem cell bearing an acquired somatic mutation in the X-linked gene ...

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