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Primary myelofibrosis 

Primary myelofibrosis

Chapter:
Primary myelofibrosis
Author(s):

Jerry L. Spivak

DOI:
10.1093/med/9780199204854.003.220309_update_003

August 28, 2014: This chapter has been re-evaluated and remains up-to-date. No changes have been necessary.

Update:

Aetiology—description of insertions/deletions of the calreticulin gene.

Updated on 27 Feb 2014. The previous version of this content can be found here.
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date: 23 May 2017

Myelofibrosis is a reactive process common to many malignant and benign disorders. Primary myelofibrosis is a chronic myeloproliferative disorder of unknown aetiology that involves a multipotent haemopoietic progenitor cell and results in abnormalities in red cell, white cell, and platelet production in association with marrow fibrosis and extramedullary haemopoiesis....

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