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Myelodysplasia 

Myelodysplasia

Chapter:
Myelodysplasia
Author(s):

Lawrence B. Gardner

and Chi V. Dang

DOI:
10.1093/med/9780199204854.003.220307
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date: 23 August 2017

Myelodysplasia is a common haematological disorder that may occur at any age, although prevalence increases with age and most patients are over 60 years old. It is associated with a wide variety of acquired clonal abnormalities that may affect all lineages of blood cells and frequently lead to the development of leukaemia. Some particular chromosomal abnormalities are characteristic, and in a few cases functional studies of candidate genes implicated in the chromosomal abnormalities suggest cause–effect relationships, e.g. an activating mutation in the JAK2 kinase....

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