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Chronic lymphocytic leukaemia 

Chronic lymphocytic leukaemia

Chapter:
Chronic lymphocytic leukaemia
Author(s):

Clive S. Zent

and Aaron Polliack

DOI:
10.1093/med/9780199204854.003.220305_update_002

Update:

Reviewed June 2013—no significant changes required.

Updated on 29 Aug 2013. The previous version of this content can be found here.
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date: 24 May 2017

Chronic lymphocytic leukaemia/small lymphocytic lymphoma (CLL) is the most prevalent lymphoid neoplasm in Europe and North America. The ‘cell of origin’ is a mature B lymphocyte that has a rearranged immunoglobulin gene. CLL cells express modest amounts of surface immunoglobulin, and are characterized by defective apoptosis. The cause of CLL is unknown....

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