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Acute lymphoblastic leukaemia 

Acute lymphoblastic leukaemia
Chapter:
Acute lymphoblastic leukaemia
Author(s):

Tim Eden

DOI:
10.1093/med/9780199204854.003.220303
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date: 25 September 2017

Genetic changes in key progenitor cells in acute lymphoblastic leukaemia (ALL) are typically either point mutations or (more frequently) translocation of proto-oncogenes to active promoter sites, with such genetic rearrangements leading to aberrant protein production. In most childhood disease the first genetic events arise in utero...

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