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Haemopoietic stem cell disorders 

Haemopoietic stem cell disorders

Chapter:
Haemopoietic stem cell disorders
Author(s):

D.C. Linch

DOI:
10.1093/med/9780199204854.003.220202
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date: 20 July 2017

The term stem-cell disorder is usually understood to imply that a disease process has begun in a primitive cell with the potential to develop into cells of different lineages. Difficulties with such a definition include (1) malignant change in a very primitive cell does not necessarily lead to the production of mature cells of multiple lineages; (2) although an immature phenotype of a malignant cell may indicate transformation of a very early cell, it is possible that transformation could arise in a later cell with subsequent dedifferentiation....

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