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The renal tubular acidoses 

The renal tubular acidoses

Chapter:
The renal tubular acidoses
Author(s):

John A. Sayer

and Fiona E. Karet

DOI:
10.1093/med/9780199204854.003.2115_update_002

Update:

Chapter updated throughout

New figure added showing an algorithm approach to a patient with hyperchloraemic metabolic acidosis.

Further reading updated to reflect most recent research

Updated on 27 Apr 2017. The previous version of this content can be found here.
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date: 23 August 2017

Renal tubular acidosis (RTA) arises when the kidneys either fail to excrete sufficient acid, or are unable to conserve bicarbonate, both circumstances leading to metabolic acidosis of varying severity with altered serum potassium. Proximal and distal types of RTA can be differentiated according to which nephron segment is malfunctioning. The condition may be secondary (e.g. associated with drugs, autoimmune disease, or diabetes mellitus) or inherited, and there may be renal tract calcification and—in chronic cases—metabolic bone disease....

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