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The kidney in rheumatological disorders 

The kidney in rheumatological disorders

Chapter:
The kidney in rheumatological disorders
Author(s):

Wai Y. Tse

and Dwomoa Adu

DOI:
10.1093/med/9780199204854.003.211003_update_001

Update:

Treatment of lupus nephritis—(1) recent publications show lower rates of renal flare in patients taking hydroxychloroquine; (2) in class V (membranous) disease ciclosporin and pulsed intravenous cyclophosphamide have both been shown to be better at inducing remission than prednisolone alone; other studies have shown that cyclophosphamide and mycophenolate mofetil are probably of equal efficacy; (3) 10-year follow up from the Euro-lupus trials shows that azathioprine is a very effective maintenance agent; (4) recent trials of biologic agents are discussed; many have not proved to be efficacious, but early results with the B-cell modulator belimumab (a human anti-BLyS antibody) show promise.

Updated on 25 May 2011. The previous version of this content can be found here.
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date: 23 June 2017

Epidemiology and clinical features of renal disease—10 to 20% of patients with SLE have evidence of renal involvement at presentation, with this subsequently developing in about 40 to 50% of cases, typically during the first 5 years after diagnosis. Presentation is with proteinuria (causing nephrotic syndrome in ...

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