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The kidney in systemic vasculitis 

The kidney in systemic vasculitis

Chapter:
The kidney in systemic vasculitis
Author(s):

David Jayne

DOI:
10.1093/med/9780199204854.003.211002_update_001

May 30, 2013: This chapter has been re-evaluated and remains up-to-date. No changes have been necessary.

Update:

Treatment: (1) Rituximab—discussion of recent clinical trials showing that this chimeric anti-CD20 monoclonal antibody is an effective alternative to cyclophosphamide for remission induction and preferable to further cyclophosphamide for relapsing or refractory disease. (2) Mycophenolate mofetil—evidence that this is less effective than azathioprine for relapse prevention. (3) Other new agents—deoxyspergualin shown to induce remission in refractory Wegener’s granulomatosis in two uncontrolled trials.

Updated on 25 May 2011. The previous version of this content can be found here.
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date: 27 June 2017

Systemic vasculitis can occur as a primary autoimmune disorder, or as a secondary manifestation of another disease process (e.g. related to infection, malignancy, chronic inflammatory disorder, or drugs). Primary systemic vasculitis is classified according to the predominant size of blood vessel involved and the presence of circulating antineutrophil cytoplasmic autoantibodies (ANCA). Incidence and prevalence rates are between 15 and 20 per million and 200 to 400 per million population, respectively. Vasculitic syndromes frequently involve the kidney, causing tissue infarction, loss of function and rapid progression to end stage renal disease within weeks or months....

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