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Chronic tubulointerstitial nephritis 

Chronic tubulointerstitial nephritis
Chapter:
Chronic tubulointerstitial nephritis
Author(s):

Marc E. De Broe

, Patrick C. D’Haese

, and Monique M. Elseviers

DOI:
10.1093/med/9780199204854.003.210902_update_001

November 28, 2012: This chapter has been re-evaluated and remains up-to-date. No changes have been necessary.

Update:

Further reading updated.

Updated on 25 May 2011. The previous version of this content can be found here.
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date: 17 October 2017

Chronic tubulointerstitial nephritis is usually asymptomatic, presenting with slowly progressive renal impairment. Urinalysis may be normal or show low-grade proteinuria (<1.5 g/day) and/or pyuria. Diagnosis depends on renal biopsy, which reveals variable cellular infiltration of the interstitium, tubular atrophy, and fibrosis. There are many causes including sarcoidosis, drugs (prescribed and nonprescribed), irradiation, toxins, and metabolic disorders....

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