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Antiglomerular basement membrane disease 

Antiglomerular basement membrane disease

Chapter:
Antiglomerular basement membrane disease
Author(s):

Jeremy Levy

and Charles Pusey

DOI:
10.1093/med/9780199204854.003.210807_update_002

Update:

Management—report of a recent large cohort study from China.

Updated on 29 May 2014. The previous version of this content can be found here.
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date: 23 May 2017

Antiglomerular basement membrane disease (anti-GBM disease, also known as Goodpasture’s disease) is a rare autoimmune disease caused by pathogenic autoantibodies directed against the noncollagenous, C-terminal domain of the α-3 chain of type IV collagen (α3(IV)NC1). Immunohistology is characteristic, with linear deposition of IgG (sometimes with IgA or IgM) and complement C3 along the GBMs....

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