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Minimal-change nephropathy and focal segmental glomerulosclerosis 

Minimal-change nephropathy and focal segmental glomerulosclerosis
Chapter:
Minimal-change nephropathy and focal segmental glomerulosclerosis
Author(s):

Dwomoa Adu

DOI:
10.1093/med/9780199204854.003.210803

May 25, 2011: This chapter has been re-evaluated and remains up-to-date. No changes have been necessary.

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date: 12 December 2017

Minimal-change nephrotic syndrome (MCNS) is an immune-mediated condition, usually of unknown cause, but which can sometimes be associated with Hodgkin’s disease or the use of nonsteroidal anti-inflammatory drugs. On light microscopy the glomeruli appear normal or small, and on electron microscopy there is effacement of epithelial-cell foot processes over the outer surface of the glomerular basement membrane. MCNS is the cause of about 80% of cases of nephrotic syndrome in children and 20% in adults....

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