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Acute kidney injury 

Acute kidney injury
Chapter:
Acute kidney injury
Author(s):

J Firth

DOI:
10.1093/med/9780199204854.003.2105_update_001

Update:

Enhanced discussion on recognition and management of hypovolaemia; further comment on possible specific treatments for patients with or at risk of AKI (fenoldopam, growth factors, N-acetylcysteine).

Updated on 25 May 2011. The previous version of this content can be found here.
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date: 20 November 2017

Definition—for practical clinical purposes, acute kidney injury is defined as a significant decline in renal excretory function occurring over hours or days. This is usually detected by a rise in the serum concentration of creatinine. Oliguria—defined (arbitrarily) as a urinary volume of less than 400 ml/day—is usually present, but not always. More precise definitions, such as those of the Risk Injury Failure Loss and Endstage kidney disease (RIFLE) classification, or the modification of this definition as proposed by the Acute Kidney Injury Network (AKIN), are required for epidemiological or trial purposes....

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