November 28, 2012: This chapter has been re-evaluated and remains up-to-date. No changes have been necessary.
Pathogenesis—expanded discussion to include specific evidence regarding genetic susceptibility.
Clinical features—new illustration of all of the typical physical features of the diagnostic criteria.
Risk stratification—inclusion of stress echocardiography, MR angiography, and CT angiography. Classification of coronary artery abnormalities updated to emphasize the use of z-scores and identified cutpoints.
Management—(1)General—encouragement of physical activity within the context of any restrictions. (2) Immunosuppressive—enhanced discussion of evidence regarding the role of corticosteroids, also of both risk prediction and alternative treatments for patients not responding to initial IVIG treatment. (3) Long term—discussion a role for intravascular ultrasound to characterize arterial wall structure, particularly in adults suspected of coronary artery complications related to Kawasaki's disease.
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