Edited by David A. Warrell, Timothy M. Cox, and John D. Firth

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Publisher:: Oxford University Press

Print Publication Date:: May 2010

Print ISBN-13:: 9780199204854

Published online:: Nov 2011

DOI:: 10.1093/med/9780199204854.001.1

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Oxford University Press makes no representation, express or implied, that the drug dosages in this book are correct. Readers must therefore always check the product information and clinical procedures with the most up to date published product information and data sheets provided by the manufacturers and the most recent codes of conduct and safety regulations. The authors and the publishers do not accept responsibility or legal liability for any errors in the text or for the misuse or misapplication of material in this work. Except where otherwise stated, drug dosages and recommendations are for the non-pregnant adult who is not breastfeeding.

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Polymyalgia rheumatica and temporal arteritis

Chapter:: Polymyalgia rheumatica and temporal arteritis

Author(s):: Jan Tore Gran

DOI:: 10.1093/med/9780199204854.003.191104_update_001

Update:

Temporal arteritis—enhanced description of ‘masked’ or ‘occult’ disease.

Pathogenesis and treatment—role of IL-6 discussed, and use of the anti-IL-6 monoclonal antibody tocilizumab.

Updated on 30 Nov 2011. The previous version of this content can be found here.

Polymyalgia rheumatica and temporal arteritis are distinct but overlapping inflammatory conditions of unknown aetiology. They almost exclusively affect people over 50 years of age, women more than men (ratio 2–3:1), and particularly those of Nordic heritage.

Temporal arteritis is characterized by granulomatous inflammation that penetrates all layers of the wall of medium and (often) large muscular arteries, in particular the superficial temporal artery. Histological examination of tissues from patients with polymyalgia rheumatica shows nonspecific changes only. The term ‘giant cell arteritis’ is properly used only to describe patients with biopsy-proven arteritis....

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