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Systemic lupus erythematosus and related disorders 

Systemic lupus erythematosus and related disorders

Chapter:
Systemic lupus erythematosus and related disorders
Author(s):

Anisur Rahman

and David A. Isenberg

DOI:
10.1093/med/9780199204854.003.191102_update_003

Update:

Biologic therapies—use of a biologic (rituximab) as initial treatment to avoid corticosteroid.

Updated on 28 Aug 2014. The previous version of this content can be found here.
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date: 23 June 2017

Systemic lupus erythematosus (SLE) is an autoimmune rheumatic disorder that can present with symptoms in almost any organ or system of the body. It is 10 to 20 times commoner in women than men, and commoner in Afro-Caribbeans than Asians than whites.

Aetiology is multifactorial, incorporating genetic, hormonal, and environmental elements. No single abnormality of the immune system can be considered responsible, pathogenesis depending on the interplay of a number of different factors, including autoantibodies, T lymphocytes, cytokines, the complement system, and apoptosis....

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