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Reactive arthritis 

Reactive arthritis
Chapter:
Reactive arthritis
Author(s):

J.S. Hill Gaston

DOI:
10.1093/med/9780199204854.003.1908_update_002

August 28, 2014: This chapter has been re-evaluated and remains up-to-date. No changes have been necessary.

Update:

Pathogenesis—new findings in genetics of ankylosing spondylitis have implications for reactive arthritis.

Updated on 28 Nov 2012. The previous version of this content can be found here.
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date: 12 December 2017

Reactive arthritis is a subset of postinfectious arthritis in which infection, usually of the gastrointestinal or genitourinary tracts, leads to inflammatory arthritis. Following infection, organisms or their components find their way to joints, where they provoke inflammatory immune responses. Whether the responses cross-react with self antigens is unclear; arthritis may be maintained by persistent infection. The disease commonly has specific extra-articular features not seen in other forms of postinfectious arthritis, and is genetically and pathologically a form of spondyloarthritis (see ...

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