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Lung transplantation 

Lung transplantation
Chapter:
Lung transplantation
Author(s):

P. Hopkins

and K. McNeil

DOI:
10.1093/med/9780199204854.003.1816_update_002

Update:

Lung donors—use of donation after cardiac death (DCD) and ex-vivo lung perfusion.

Surgical technique—discussion of approach to patients with severe lung hyperinflation.

Prevention of infection—new recommendations on prophylaxis against CMV after donor positive/recipient negative transplantation.

Transplant rejection—description of acute humeral rejection.

Updated on 30 May 2013. The previous version of this content can be found here.
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date: 17 October 2017

Lung transplantation offers the only therapeutic option for many patients with a variety of endstage pulmonary and cardiopulmonary diseases, but donors are scarce and the major challenge facing lung transplantation (as with all solid organ transplants) is the critical shortage of donor organs.

Recipient selection—emphysema/chronic obstructive pulmonary disease (COPD), cystic fibrosis, idiopathic pulmonary fibrosis, and pulmonary vascular disease are the main disease groups referred for lung transplantation. Most patients are listed for transplantation when their survival is estimated to be less than 2 years without a transplant. Exclusion criteria include malignancy (excluding localized skin malignancies) within the last 2 years, inability to cooperate or comply with medical therapy/instruction, recent substance addiction, active or noncurable extrapulmonary infection, significant chest wall/spinal deformity, and significant extrathoracic organ dysfunction....

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