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Therapeutic anticoagulation 

Therapeutic anticoagulation

Chapter:
Therapeutic anticoagulation
Author(s):

David Keeling

DOI:
10.1093/med/9780199204854.003.161602_update_002

Update:

Enhanced discussion of indications for and use of oral direct inhibitors of thrombin and factor Xa.

Updated on 29 Oct 2015. The previous version of this content can be found here.
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date: 23 May 2017

Low molecular weight heparins (LMWH) have largely replaced unfractionated heparin. Their much more predictable anticoagulant response combined with high bioavailability after subcutaneous injection means that the dose can be calculated by body weight and given subcutaneously without any monitoring or dose adjustment. Their widespread use resulted in most patients with deep vein thrombosis being managed as outpatients, and this is also increasingly the case for uncomplicated pulmonary embolism....

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