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Alcoholic liver disease 

Alcoholic liver disease

Chapter:
Alcoholic liver disease
Author(s):

Stephen F. Stewart

and Chris P. Day

DOI:
10.1093/med/9780199204854.003.152201_update_001

Update:

Treatment for alcoholic hepatitis updated to reflect negative trials of etanercept and MARS and positive trials of N-acetylcysteine and early transplantation.

Recommendations on pharmacotherapy updated to include nalmefene.

Updated on 28 Nov 2012. The previous version of this content can be found here.
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date: 22 July 2017

The incidence of alcoholic liver disease (ALD) follows the trend of per capita alcohol consumption, with hepatic injury which extends from fatty liver to alcoholic hepatitis and cirrhosis. It is unclear how alcohol causes liver disease, but postulated mechanisms include (1) oxidative stress and acetaldehyde generated by the metabolism of ethanol, and (2) innate and adaptive immune responses. Factors determining the susceptibility to liver disease in heavy drinkers are believed to include a variety of host and environmental factors....

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