Show Summary Details
Page of

Vascular and collagen disorders 

Vascular and collagen disorders

Chapter:
Vascular and collagen disorders
Author(s):

Graham Neale

DOI:
10.1093/med/9780199204854.003.1517
Page of

PRINTED FROM OXFORD MEDICINE ONLINE (www.oxfordmedicine.com). © Oxford University Press, 2015. All Rights Reserved. Under the terms of the licence agreement, an individual user may print out a PDF of a single chapter of a title in Oxford Medicine Online for personal use (for details see Privacy Policy).

date: 19 August 2017

A wide range of vascular and collagen disorders may affect the gastro-intestinal tract. Most are quite uncommon but presentations are often dramatic with intestinal bleeding or gangrene.

Vascular insufficiency leading to ischaemic damage of the gut may be caused by occlusion of mesenteric vessels by either arterial thrombosis (usually with atheromatous pathology); or venous thrombosis (in thrombophilic conditions); or arterial emboli (as occurs with atrial fibrillation); or diffuse small vessel occlusion. There are four primary syndromes. (1) Acute mesenteric ischaemia—typically manifest as the sudden onset of abdominal pain, initially without marked tenderness or localizing signs. Diagnosis requires a high index of suspicion and is often delayed. Imaging serves primarily to exclude other causes of an apparent abdominal catastrophe but prompt laparotomy for embolectomy and/or arterial re-construction and/or bowel resection is required to minimize damage to the gut. (2) Chronic mesenteric ischaemia—usually due to atheroma, presents with severe cramping abdominal pain 20 to 60 min, after eating. Diagnosis requires vascular imaging and usually the condition can be relieved only by revascularization. (3) Ischaemic colitis—presents with pain and tenderness in the left iliac fossa, nausea and vomiting, followed by the passage of a loose motion containing dark blood. Contrast enema examination characteristically shows ‘thumbprinting’ of the colonic mucosa. Most cases resolve spontaneously so supportive management is usually sufficient. (4) Ischaemia–reperfusion injury—diminishes the barrier function of the gut and may lead to septicaemia in those who are already critically ill....

Access to the complete content on Oxford Medicine Online requires a subscription or purchase. Public users are able to search the site and view the abstracts for each book and chapter without a subscription.

Please subscribe or login to access full text content.

If you have purchased a print title that contains an access token, please see the token for information about how to register your code.

For questions on access or troubleshooting, please check our FAQs, and if you can't find the answer there, please contact us.