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Crohn’s disease 

Crohn’s disease

Chapter:
Crohn’s disease
Author(s):

Miles Parkes

DOI:
10.1093/med/9780199204854.003.1511_update_002

Update:

Updated information regarding Crohn’s disease pathogenesis, optimization of thiopurine therapy and initiation and cessation of anti-TNF therapy. In particular, evidence for the benefit of combination anti-TNF therapy with thiopurine (from the SONIC study) and criteria for stopping anti-TNF therapy (from the STORI study).

A relevant case history from Oxford Case Histories in Gastroenterology and Hepatology has been added to this chapter.

Updated on 28 Nov 2012. The previous version of this content can be found here.
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date: 24 May 2017

Case History—A 22 yr old woman presenting with a two-year history of diarrhoea, intermittent abdominal pain and weight loss.

Crohn’s disease is a common form of chronic inflammatory bowel disease. Typically involving the terminal ileum, colon, and perineum, it causes patchy transmural inflammation characterized microscopically by granulomata. Common complications include fibrotic strictures, fistulas, and abscesses....

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