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Whipple’s disease 

Whipple’s disease

Chapter:
Whipple’s disease
Author(s):

H.J.F. Hodgson

DOI:
10.1093/med/9780199204854.003.151006_update_001

Update:

Clinical and diagnostic features; further reading added.

Updated on 28 Nov 2012. The previous version of this content can be found here.
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date: 18 August 2017

Whipple’s disease is an uncommon infection caused by the actinomycete Tropheryma whipplei. It is most commonly diagnosed when overt small-intestinal disease leads to malabsorption, but before this there are often several years of nonspecific prodromal manifestations such as fever and arthralgia/arthritis, and the disease can present in many other ways, e.g neurological manifestations (of many forms, including movement disorders, ocular manifestations and meningitis) or endocarditis....

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