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Coeliac disease 

Coeliac disease

Chapter:
Coeliac disease
Author(s):

Patrick C.A. Dubois

and David A. van Heel

DOI:
10.1093/med/9780199204854.003.151003_update_001

Update:

Additional information on duodenal bulb biopsies, anti-deamidated gliadin peptide (DGP) antibodies, and pneumococcal vaccination.

A relevant case history has been added.

Updated on 28 Nov 2012. The previous version of this content can be found here.
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date: 28 June 2017

Case History—A 38 yr old woman presenting with a long history of tiredness and abdominal bloating.

Coeliac disease is a common disorder of the small intestine in which storage proteins in dietary wheat, rye, and barley (gliadin, secalins, hordeins, usually referred to as ‘gluten’) induce T-cell responses restricted by HLA DQ2 or DQ8. This immune response drives intestinal inflammation and loss of villous architecture and can lead to a wide spectrum of clinical manifestations....

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