Show Summary Details
Page of

The pineal gland and melatonin 

The pineal gland and melatonin

Chapter:
The pineal gland and melatonin
Author(s):

J. Arendt

and T.M. Cox

DOI:
10.1093/med/9780199204854.003.1313_update_001

Update:

Expanded discussion of melatonin biosynthesis, receptors, role in photoperiodism, clinical use; also of the possible implication of melatonin in the reported cancer risk of shift workers and with regard to commercial preparations of melatonin and its analogues.

Updated on 30 Nov 2011. The previous version of this content can be found here.
Page of

PRINTED FROM OXFORD MEDICINE ONLINE (www.oxfordmedicine.com). © Oxford University Press, 2015. All Rights Reserved. Under the terms of the licence agreement, an individual user may print out a PDF of a single chapter of a title in Oxford Medicine Online for personal use (for details see Privacy Policy).

date: 25 July 2017

The pineal gland transduces light–dark cycles into body rhythms by secretion of melatonin, an endogenous indoleamine derived from tryptophan, the concentrations of which in plasma and cerebrospinal fluid are up to 100 times higher at night than in the daytime. This exerts its effects through transmembrane, G-protein coupled receptors (MT1 and MT2) and nuclear receptors in the pituitary gland and hypothalamus....

Access to the complete content on Oxford Medicine Online requires a subscription or purchase. Public users are able to search the site and view the abstracts for each book and chapter without a subscription.

Please subscribe or login to access full text content.

If you have purchased a print title that contains an access token, please see the token for information about how to register your code.

For questions on access or troubleshooting, please check our FAQs, and if you can't find the answer there, please contact us.