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Hormonal manifestations of nonendocrine disease 

Hormonal manifestations of nonendocrine disease

Chapter:
Hormonal manifestations of nonendocrine disease
Author(s):

T.M. Barber

and John A.H. Wass

DOI:
10.1093/med/9780199204854.003.1312_update_001

July 30, 2015: This chapter has been re-evaluated and remains up-to-date. No changes have been necessary.

Update:

Syndrome of inappropriate antidiuresis (SIAD)—discussion of use of vasopressin (V2) receptor antagonists.

Ectopic ACTH secretion—new discussion of gene expression profiles in tumour producing ectopic ACTH versus Cushing’s disease tumours.

New section on the endocrine manifestations of obesity.

Updated on 30 Nov 2011. The previous version of this content can be found here.
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date: 27 June 2017

Tumours (usually but not invariably malignant), other ‘nonendocrine conditions’ and drugs can be associated with a wide variety of endocrine syndromes. ‘Ectopic’ hormone secretion, defined as the release of a hormone from a site different from the gland that normally produces it, has classically been recognized in the context of neoplasia, but it is now apparent that many hormones are synthesized by ‘nonendocrine’ tissue. Although a particular endocrinopathy may be associated with a specific type of tumour in a particular organ, the relationship is not invariable, and many neoplasms elaborate more than one hormonal substance at the same or at different times and thus produce a mixed endocrine picture....

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