- 1 On being a patient
- 2 Modern medicine: foundations, achievements, and limitations
- 3 Global patterns of disease and medical practice
- 4 Cell biology
- 5 Immunological mechanisms
- 6 Principles of clinical oncology
- 7 Infection
- 8 Sexually transmitted diseases and sexual health
- 9 Chemical and physical injuries and environmental factors and disease
- 10 Clinical pharmacology
- 11 Nutrition
- 12 Metabolic disorders
- 13 Endocrine disorders
- 13.1 Principles of hormone action
- 13.2 Disorders of the anterior pituitary gland
- 13.3 Disorders of the posterior pituitary gland
- 13.4 The thyroid gland and disorders of thyroid function
- 13.5 Thyroid cancer
- 13.6 Parathyroid disorders and diseases altering calcium metabolism
- 13.7 Adrenal disorders
- 13.7.1 Disorders of the adrenal cortex
- 13.7.2 Congenital adrenal hyperplasia
- 13.8 The reproductive system
- 13.9 Disorders of growth and development
- 13.10 Pancreatic endocrine disorders and multiple endocrine neoplasia
- 13.11 Disorders of glucose homeostasis
- 13.12 Hormonal manifestations of nonendocrine disease
- 13.13 The pineal gland and melatonin
- 14 Medical disorders in pregnancy
- 15 Gastroenterological disorders
- 16 Cardiovascular disorders
- 17 Critical care medicine
- 18 Respiratory disorders
- 19 Rheumatological disorders
- 20 Disorders of the skeleton
- 21 Disorders of the kidney and urinary tract
- 22 Disorders of the blood
- 23 Disorders of the skin
- 24 Neurological disorders
- 25 The eye
- 26 Psychiatry and drug related problems
- 27 Forensic medicine
- 28 Sports medicine
- 29 Geratology
- 30 Pain
- 31 Palliative medicine
- 32 Biochemistry in medicine
- 33 Acute medicine
Congenital adrenal hyperplasia
- Congenital adrenal hyperplasia
Aetiology and biochemistry—description of new mutations. Reference to the ‘backdoor’ pathway to androgen production now identified in the human fetus and operating for the first year of life.
Treatment—emphasisis that prenatal treatment with maternal dexamethasone may affect gender role behaviour in boys exposed in utero and hence remains experimental and should only be undertaken in the context of clinical trials.
Discussion of use of modified release formulations of glucocorticoids.
Clinical features in the adult—health status review reveals a catalogue of ill-health and reduced quality of life, with patchy attendance at specialized endocrine centres.
Discussion of pregnancy rate.
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