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Lysosomal disease 

Lysosomal disease

Chapter:
Lysosomal disease
Author(s):

P.B. Deegan

and T.M. Cox

DOI:
10.1093/med/9780199204854.003.1208_update_003

Update:

Lysosomal function – new understanding of the central signaling complex that controls tissue and cell growth

Treatment – extensive discussion of many new agents for many lysosomal diseases, particularly enzyme replacement therapies, molecular chaperone therapies and substrate reduction therapies.

Updated on 30 Jul 2015. The previous version of this content can be found here.
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date: 23 May 2017

The lysosome is an intracellular organelle that recycles biological macromolecules derived either endogenously, from digestion of cellular components (autophagy), or from the breakdown of material that has been incorporated from outside the cell by, for example, phagocytosis. The lysosome is now known to be involved in nutrient sensing and central to the regulation of the metabolic economy of the cell....

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