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Buruli ulcer: Mycobacterium ulcerans infection 

Buruli ulcer: Mycobacterium ulcerans infection
Chapter:
Buruli ulcer: Mycobacterium ulcerans infection
Author(s):

Wayne M. Meyers

, Bouke de Jong

, and Françoise Portaels

DOI:
10.1093/med/9780199204854.003.070628_update_002

Update:

Aetiology—discussion of data from whole genome sequencing of M. ulcerans.

Epidemilogy and transmission—role of possums as reservoir in South Eastern Australia.

Updated on 29 May 2013. The previous version of this content can be found here.
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date: 17 October 2017

Buruli ulcer is caused by Mycobacterium ulcerans, which secretes a cytotoxic and immunosuppressive toxin, mycolactone. The disease is characterized by necrosis of skin, subcutaneous tissue, and bone, and is re-emerging as a potentially disabling affliction of inhabitants of tropical wetlands. Major foci are in West and Central Africa, but there are minor endemic foci in Australia, Mexico, South America, and South-East Asia. It is not contagious; environmental sources include water, vegetation, and insects, with humans probably becoming infected by traumatic introduction of the bacillus into the skin from the overlying ...

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