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Clostridium difficile 

Clostridium difficile
Chapter:
Clostridium difficile
Author(s):

John G. Bartlett

DOI:
10.1093/med/9780199204854.003.070623_update_001

Update:

Diagnosis—molecular diagnostic methods.

Treatment—fidaxomicin.

Further reading—updated references for PCR and fidaxomicin trial.

Updated on 31 May 2012. The previous version of this content can be found here.
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date: 24 November 2017

Clostridium difficile is a Gram-positive spore-forming anaerobic bacillus found in the environment. Its spores are part of the colonic flora in about 2 to 3% of healthy adults, with colonization rates increasing during hospitalization to 20 to 40%. Disease occurs when the organism shifts to its replicating vegetative form with toxin (A and B) production, this typically happening when there is inhibition of the competing colonic flora by antibiotics. ...

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