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Francisella tularensis infection 

Francisella tularensis infection

Chapter:
Francisella tularensis infection
Author(s):

Petra C.F. Oyston

DOI:
10.1093/med/9780199204854.003.070619_update_001

May 30, 2013: This chapter has been re-evaluated and remains up-to-date. No changes have been necessary.

Update:

Epidemiology.

Pathogenesis (including mechanisms for intracellular survival and identification virulence genes).

Laboratory identification.

Updated on 31 May 2012. The previous version of this content can be found here.
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date: 25 July 2017

Fransicella tularensis is a small Gram-negative coccobacillus that circulates in small rodents, rabbits and hares, most frequently in Scandinavia, northern North America, Japan, and Russia. Clinical presentation depends on the route of infection. Most commonly this follows the bite of an infected arthropod vector, resulting in ulceroglandular tularaemia. The most acute and life-threatening disease, respiratory or pneumonic tularaemia, arises following inhalation of infectious aerosols or dusts. The organism is highly fastidious, requiring rich media for isolation and specialized reagents for positive identification; most cases are diagnosed serologically. Treatment is with supportive care and antibiotics (usually ciprofloxacin, doxycycline or gentamicin). There is no vaccine....

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