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Haemophilus ducreyi and chancroid 

Haemophilus ducreyi and chancroid

Chapter:
Haemophilus ducreyi and chancroid
Author(s):

Nigel O’Farrell

DOI:
10.1093/med/9780199204854.003.070613_update_001

February 27, 2014: This chapter has been re-evaluated and remains up-to-date. No changes have been necessary.

Update:

Histological and immunophenotypic features of chancroid.

Interaction between HIV infection and chancroid.

Updated on 31 May 2012. The previous version of this content can be found here.
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date: 25 March 2017

Haemophilus ducreyi is a Gram-negative, facultative anaerobic bacillus that is the cause of chancroid, which is endemic in sub-Saharan Africa and the Caribbean, although the overall global incidence of the condition has decreased dramatically since the mid 1990s.

Clinical features—After an incubation period of 4 to 10 days, presentation is with a tender genital papule that develops into a pustule and then an ulcer with a ragged undermined edge and a yellow base that bleeds readily. The usual sites of infection in men are the prepuce and coronal sulcus, and in women the labia minora and fourchette. Inguinal lymphadenopathy is found in about half the male cases. Chancroid is an important risk factor for the transmission of HIV infection. HIV infection may result in atypical manifestations if chancroid.

Diagnosis and treatment—nucleic acid amplification tests are the optimal method of diagnosing H. ducreyi. Treatment is with ciprofloxacin, erythromycin, azithromycin, or ceftriaxone.

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